CHECK THE BARREL to see if the last round is still in it. This happened to me for the first time on my FNX at the range last week. Yes it was a re-loaded round, and yes, I apparently failed to charge the case.
I have also had two reloaded rounds fail to go into battery in my CZ, but upon inspection, it turned out to be two defective rounds. (Bullets inserted crooked, causing a bulge in the case)
Look it over carefully, and try very hard to identify the problem before shooting any more rounds.