For many years me and a guy I used to always hunt with never strayed from the two rifles we carried, him a 270 and me a 30-06. I think he had a slight advantage in trajectory and I had a slight advantage with being able to handle heavier bullets.
But the truth is, any shot where such a flat-shooting advantage might have actually factored in, would have pretty well been beyond the range that either of us had any business trying to take on game. Also, we weren't going to be hunting anything so big and tough that an advantage in heavier bullets would be much of a plus either.
I've shot his rifle, he has shot mine, neither of us have ever noticed much difference in recoil or noise. Both of us have managed to pick up a few other rifles as time has went by, but aside from maybe being a bit easier to carry and more compact- none of them do the job any better than those two we each started with and still own.
Bottom line is they are both a couple of the best calibers available.