Best of luck and be ready to do some tracking. The main problem I've seen with 45ACP is with a JHP load, lack of an exit wound and with most FMJ/roundnose, not much shock. If your pistol will handle 45 Super loads a 255gr hardcast flat point would be a good choice. If limited to 45ACP use a heavy hardcast flat point like Buffalo Bore's 255gr +p load or the similar Underwood loading.
For short range deer hunting with a handgun I prefer heavy for caliber Keith style or semi wadcutter bullets in a revolver. Usually a 260 to 300gr bullet in a 44 Special or a 300 to 325gr bullet in a 45 Colt. Those bullets will break bones, punch through and leave an exit wound with a good blood trail.