Honestly, the TS variants have a lot of real estate for your hands. The extended safety is a perfect perch for your strong hand thumb and your weak hand should nestle in under it nicely. I have big hands (use palm swell Bogies on my TSO's) and I don't have issues with the safety digging into my weak hand.
I did have issues with the CZCustom wide shelf extended safety lever digging into my weak hand. I had to take a dremel and deburr the edges and reshape it which helped but didn't eliminate it all together. I purchased the stock CZ extended safety lever (originally the TSO didn't come with wide safety levers), and that issue is completely gone.
FYI, this thread should be in the SP01 and other variants section.
Cheers,
Toby