My P01 has a light on it, a TLR3. I only have the one holster for it. An IWB kydex holster from the Cleveland Kydex Co.
I've tried carrying it. It's uncomfortable. That's a holster issue and body shape issue (my spare tire).
The light also makes it harder to pull from the holster. I've not found it harder to put the pistol in the holster, but it does not pull out of the holster as smoothly as it does without the light on it, or as smoothly as other guns in other holsters without a light.
Shooting it is a non-issue. I don't even know the light is on it.