The last .22LR ammo I bought was 500-round bricks of Remington Thunderbolt and it was around $7-8 per brick. It was easy to go through a brick at a day at the range. I still have 2 bricks, but I don't shoot the .22s that much anymore since I am not willing to replace that ammo with the current prices they are charging for .22s. As such, I got into reloading and for pretty much any handgun caliber, I can reload it for around $2.50-3.50 per 50-round box as long as I can recover my brass. The two variable costs for reloading are the powder and the bullet. Of these, the biggest cost is the lead, so lighter bullets make for cheaper ammo. I usually figure on $1-1.25 per pound for lead. Wheelweights used to be the best source for a good lead alloy, but these days, you're lucky to get a 50% lead return from a 5g bucket of wheelweights thanks to all the eco-weenies and their push to move away from lead in wheelweights. Lately, I've been finding mostly steel plus the occasional zinc one when I get a 5g bucket from a tire shop.
The round that I see as a potential replacement for the .22LR for me is the .22 TCM. I already have a 0.224" 55gr mold and I suspect that I can work up a load with that would be a good plinking round with a cheap powder without having to go all out and load for full blown .22 TCM ballistics. Of course, if you are shooting either a single shot or bolt action rifle or a revolver (handgun) your reloading options are quite a bit more flexible than if you are shooting a semi-auto.