The initial blow-out for the bottom case was at the extractor groove. This area is ALWAYS exposed, so it wasn't an unsupported chamber, as that area is always unsupported. Also, a proper .45 load simply doesn't have the pressure to blow out like that and certainly NOT to set off the next round.
Was the case head expanded on the fired case? That is a sure sign of over-pressure.
That kind of blow-up is almost always due to over-pressure (accidentally used the wrong powder or the wrong powder charge) and less likely to be a bad case. Not sure what caused the next case to blow, as the escaping gasses had to be very hot.
The one time I had a case rupture (.40S&W), it broke the extractor and blew out the bottom of the magazine, but the top round in the magazine showed not particular issue other than some surface soot.