I would say : YES
However it depends, how you feel gun in your hand, how you grip the gun.
Weight difference between alu and steel frame is about 5oz - 6 oz. Is it much?
For me it was. I've shot polymer PPQ (22 oz.) and decided to switch it for heavier pistol. Steel CZ75 Compact's weight was too much for me (about 33 oz.).
My choice now is alu CZ P-01 (about 28 oz.) and that's the weight I love.
So from my perspective the weight difference is really noticeable.