I have CCW a Glock, with one in the chamber, in an OWB holster in the past. Honestly though it makes me a bit paranoid to carry a striker-fired gun like that, even more so if it were carried IWB, when re-holstering it. If I were going to carry one now, I'd probably get a Glock and install one of those striker control gadgets, so I could "ride the hammer" into the holster like I do with my hammer-fired guns.
These days I personally CCW a P-07 decocked, a DAO Sig P290RS, or occasionally my old J-frame revolver. I can carry any of these without any worries, because I can ride the hammer with my thumb when re-holstering. Each is an uncocked DA gun with a long trigger pull, at least for the first shot, each also with a firing pin block to prevent accidental discharge in case of being dropped or other mishap that causes the hammer or something else to smack the back of the firing pin without the trigger being pulled. None of them have manual safeties. They all work more or less the same way and I feel comfortable carrying any of them, holstered, with one in the chamber, either IWB or in a pants or jacket pocket.