Pretty sure you're the first and this is going to be a trial and error thing. Start small, test, open it up a little, test, etc. If you can't shoot nearby to your drilling tools, you might try precision drilling a starter hole smaller than you think is needed, then using a hand tool at the range to open up the hole until desired function is achieved.
If you can lay hands on a high speed camera (there are some cheap enough to use for diagnostics like this), you can compare the bolt velocity when the rifle is unsuppressed/normal gas setting to your suppressed/suppressor gas setting and stop enlarging the hole when comparable timing is achieved.