1. Pick a caliber
45ACP is a low pressure round and VERY forgiving. 9x19 is high pressure requiring a few more tricks, but costs a lot less. Sooner or later you'll be forced to do the same procedure for BOTH rounds. Just pick one you have the components for and put the other
completely aside. Master a single caliber first.
2. Build "test cartridges"
If you are unsure of an OAL, pick a higher number between the 2 limits and build a longer "test cartridge" with case and bullet ONLY. Put the TC in the mag and sling shot the slide. Did it feed? You can reseat the bullet .010" deeper and try again if you like. After all these trials, pick an OAL for each particular bullet and stay with it until hell freezes or poor feeding makes you change your mind.
3. Go by the book
If your published load is "3.9 to 4.9gr", then load: 6-8 rounds at 3.9gr, 6-8 rounds at 4.1gr, 6-8 rounds at 4.3gr, 6-8 rounds at 4.5gr, and 6-8 rounds at 4.7gr. (We don't mess with the top end.) Label them VERY clearly.
4. Shoot them
Starting with the lowest and working up, shoot them at something like 30 feet, each group at a fresh target
from a supported position. Be sure and transfer the label on the ammo to the targets. Stop when the pressure signs get excessive and disassemble the remaining rounds.
5. Judge them at home
Take all your targets home. I like to throw out the worst shot on each, but I also collect stray cats and Sasquatches. Study them under a light with a caliper. The lowest load that gave the smallest group is what your gun likes. Later on, you can go up 0.1gr or more if they are not fast enough for competition.
6. Mark it down
You won't remember these details after 5 or 6 different test sessions, SO WRITE IT DOWN. Set aside 1 full page for each bullet in a reloading notebook. List the bullet details and OAL on the first 10 lines, then all the powders you tried below that.
7. Have fun
Enjoy. Now you can load hundreds knowing you developed the best load for your gun that is also the most economical.
8. 2 powders
If you have 2 different powders for 1 caliber you can develop them side-by-side using the same method, but your labeling must be really good. You might find 1 of these is preferable over the other at low speeds. You might see the other excel at higher speeds. Maybe a difference in smoke, recoil, muzzle flash, or other minor annoyance. You never know.