I just got some new ammo (factory reloaded) which worked out quite well except for a handful of unfired primers needing a second hit, but pretty much all of my shooting was off. Granted, I haven't shot in about 1.5 months because I was out of ammo and buried with exams, but I have never had so many shots fly wide right before, even when I first started shooting (i.e., never had a problem with thumbing).
In my mind, it doesn't seem possible for ammo to change its POI left and right, only up and down (which I did notice, the bullets shot quite low, but they also shot a whole lot lighter than my Blazer Brass). It's also possible for my sights to have been messed up since I do have fully adjustable rear sights. Then again, I was experimenting with shooting using a slightly different grip keeping my weak hand thumb off the frame of the gun, but I figured that would have caused bullets to hit left, no right (right handed shooter).
Hope that was clear!