I carry/shoot only thumb safety models.
I daily carry a modified CZ75 Compact. I like it a lot.
But, I have a couple P01 Omegas (with safeties installed) and one of them (the black one) is going to be my EDC 9MM. There shouldn't be a difference in holding a CZ75 Compact or a P01, but for me there is. It's got to be those vertical grooves in the front/back of the grip frame on the P01 that calls me to it. There's something different about grabbing the P01 and that's got to be it. It just feels better in my hand than the other metal framed CZ's I own/shoot.
The decocker models, if that's the direction you lean, still have those grooves in the frame. Try to find one of each to look at, hold in your hand and see what you think.