I don't think you'll be very happy with HS-6. It's one of the most accurate powders I ever tested, but in my load range it was even dirtier than Unique. Leaves a big mess. In something like 357Mag, 38 Super or 10mm it might do really well.
Stick with W231/Hp-38, WSF, N320, N330, Sport Pistol, Silhouette, Ba9, even BE-86 for 9mm.