my shooting partner has both (well the Target II) and he went with the Target II
his hands a little smaller than mine so the trigger reach was more comfortable for him on the II
also the trigger out of the box is a little better on the Target II than the S2, especially the lack of creep in SA mode.
I stayed with the S2 because I like the size and weight. I've now had the slide milled for CO changed out all of the springs and have an
S2 disco I am going to install, so I'm all in with this thing.
I like shooting both but still prefer the S2.