There are 2 schools of thought for me regarding this, and they both need to take sight height over bore and bullet velocity into account:
1: The bullet will rise to the dot but no further
2: The bullet will rise over the dot, then drop back down below
If you are sighting at 25 to 50 yards, 2 is what is going to happen, obviously.
With 1, close shots will need to be aimed below the dot, but they will be very predictable at medium range, and you never "overshoot" the target. Longer shots than the drop will be fail
The alternative option with 2 is to resight in the dot at a longer range, and you sight it when the bullet drops, not raises. Then double check your closer range impacts so you know what is happening. For a PCC I would want it to drop to the dot closer or at 100yds, or more specifically the max range where I can identify a target as a threat, and also remember at that range it takes around 1/3 of a second for the bullet to reach the target