The progression I have is from .22 to 9mm to .45 cal, so not quite to the 10mm, so I can only tell you what I experienced going to the .45. I was not comfortable shooting it until I had a lot of rounds through it. But now, it is about my favorite gun. Now my CZ-97B"E" is probably heavier than your Glock in 10 mm, and that makes it easier to shoot comfortably, but I had a flinch for a while, especially shooting single hand standing under a shed.
If I had just gotten a large caliber pistol, I think what I would do is shoot it from a rest for a while, maybe at 25 yards or so, until I was confident in my ability to fire the pistol without any hesitation or flinch. The bench rest takes some of the unknowns out of the picture, and will let you become comfortable releasing a round. You can also get a better indication of what group sizes are likely to be achieved under steadier conditions than two-handed standing.
Some dry fire will also help you become comfortable with the pistol size and grip shape and trigger pull.
If you find that the gun is really good mechanically (accurate) when shooting from a rest, it will make learning to shoot it well standing two handed much more interesting to you.
Shooting from a rest for accuracy, also slows you down and will help you maximize the benefit you get from each round.
Perhaps some folks with experience with 10mm and larger will chime in. I don't want to shoot anything more violent than a lightly loaded .45 myself. And I've done that today already.
Joe