Have killed large Deer with the standard pressure .45 ACP and it works just fine. For larger and more dangerous Predators, I would choose a .454 Casull Revolver. Probably a Ruger Super Redhawk.
Then there's also a possible conversion of your 97B to .45 Super. Just add a Sprinco Recoil Reducer and an 18 lb Wolff Recoil Spring and you're there. However, the .45 Super, like many other Cartridges, is largely a Handloading proposition. I've converted my older .45 Witness to .45 Super on occasion and it really hits hard! Have not killed anything with it yet, as it's largely been backup to my .30/06 when hunting Feral Hogs. The .30/06 has always gotten the job done! So far.
Ballistically, my .45 Super handloads run a surplus Remington 185 grn JHP at 1170 fps, which is a conservative loading.