These days, the most likely reason to break into a residence is to steal a gun. No one wants your TV, stereo or jewelry anymore. Those big items are hard to carry away and have no value.
If you bolt a gun safe to a nightstand within easy reach, a thief will simply bust up the nightstand and take the whole safe with them. If you bolt it to something solid, like the floor, getting access to your gun will be severely limited. So to me, the main use of a bedside safe is to keep children from having access to your gun and nothing more.
If there are no children in the home, IMHO it's better then to conceal the weapon in a hidden compartment within the nightstand. I once had a nightstand with a hinged top that opened to reveal a shallow concealment space. When weighted down with a dozen books in the lower section, and covered with magazines and sleeping paraphernalia on the top, one would never suspect what it held. The cost of that was a set of small hinges and a piece of plywood.
Consequently I have never seen the need or expense for the small gun safe.