Due to the higher pressures used in rifle rounds, SR primers are going to have a thicker cup than even magnum small pistol. If your pistol has issues with magnum primers (or even plain old CCI primers), then rifle is going to be even worse.
I can get small rifle primers to fire consistently in my 1911, but I think you'd have a significant problem in a gun that had any modifications to the firing pin, FP spring, hammer or hammer spring. But I've been proved wrong before. I'd certainly like to hear the results of your experiments.